The Relation of Age to the Occurrence of Adenoma- Like Lesions in the Rat Hypophysis and toTheir Growth After Transplantation*
نویسنده
چکیده
The spontaneous occurrence of chromophobe adenomas and focal hyperplasia in the rat hypophysis has been reported by Wolfe, Bryan, and Wright (I8), and by Oberling, Sanni6, and the Gu6rins (I3). Hyperplasia of chromophobic ceils and the development of chromophobe adenomas in the rat hypophysis following injection of estrogens have been described by Wolfe and Wright (O) , by Zondek (2o), and by McEuen, Selye, and Collip ( i I). References to tumors of the rat hypophysis, either spontaneous or induced, are not frequent in the literature, and no reference to attempts at transplantation could be found. The purposes of this paper are to report the high incidence with advancing age of adenoma-like lesions of chromophobe cells in a strain of albino rats, to describe an experiment in which successful growth was obtained by homologous transplantation, and to discuss the possible factors necessary for growth following transplantation. The results of assays of adenoma-like tissue for hypophyseal hormones are also described.
منابع مشابه
Chromophobe Adenoma-Like Lesions of the Rat Hypophysis Frequency of the Spontaneous Lesions and Characteristics of Growth of Homologous Intraocular Transplants*
In a study of spontaneous diseases that occur in albino rats with advance in age, chromophobe adenoma-like lesions were found in the bypophyses of many old rats of the Yale strain. The frequency of this lesion in a limited series of animals, and the prel iminary results of intraocular transplantation of one of the lesions, have been reported (8). Periods of 7 to 12 months elapsed before growth ...
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